As I see it, 30% of Americans are preparing themselves for a one-party rule. They will make the rules without input from the other 70%.
It is also plausible the political left could take a pre-emptive strike and create their own one-party rule.
I'm not sure a sustained one-party rule is possible in the USA. But attempts could be made. Expect a lot of civil unrest.
You might be interested in my Orwellian Ratio, which is the historical pattern of how societies have created their hierarchies. The middle class is disappearing because we are going back to our natural ways, even in a democracy!
https://medium.com/politically-speaking/the-orwell-society-71456d100f1d
As for the universities, the conservative blue pill is that the universities are full of leftists. Yet most faculties--like engineering, dentistry, and business--are not aligned politically. It is only in the humanities--like psychology and sociology--where we find the left-wing bias. There is a bias because conservative thought is not compatible with these sciences: people need only put themselves up by their bootstraps and they can be millionaires. The humanities look for other reasons of individual and societal behavior and frustration: sometimes they are right, sometimes not.
Unlike most of the humanities, economics is something that has a right-wing bias to it. So it's hard to say that left-wingers have total control of the universities.